Cart
sales@molnova.com
β-Elemonic Acid
CAS No. 28282-25-9
β-Elemonic Acid( —— )
Catalog No. M18358 CAS No. 28282-25-9
Beta-Elemonic acid inhibits proliferation by inducing hypoploid cells and cell apoptosis, the anticancer effects of beta-Elemonic acid are related to the MAPK signaling pathway, ROS activation and glutathione depletion in human A549 lung cancer cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 86 | In Stock |
|
| 10MG | 149 | In Stock |
|
| 50MG | 358 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product Nameβ-Elemonic Acid
-
NoteResearch use only, not for human use.
-
Brief DescriptionBeta-Elemonic acid inhibits proliferation by inducing hypoploid cells and cell apoptosis, the anticancer effects of beta-Elemonic acid are related to the MAPK signaling pathway, ROS activation and glutathione depletion in human A549 lung cancer cells.
-
DescriptionBeta-Elemonic acid exhibits anti-inflammatory effects. Beta-Elemonic acid inhibits proliferation by inducing hypoploid cells and cell apoptosis, the anticancer effects of beta-Elemonic acid are related to the MAPK signaling pathway, ROS activation and glutathione depletion in human A549 lung cancer cells. Beta-Elemonic acid exhibits prolyl endopeptidase inhibitory activities.
-
In Vitroβ-elemonic acid (1, 3, 10, 20 μM; 24 hours) strongly induces human A549 lung cancer cell apoptosis in a dose- and time-dependent manner. β-elemonic acid (1, 3, 10, 20 μM; 24 hours) exerts potent cytotoxic effects on human NSCLC A549 cells in a dose-dependent manner. The IC50 value following a 24-h exposure to β-elemonic acid was 6.92 μM. β-elemonic acid (20 μM; 24 hours) results in a cell percentage of 58.01% in the G0/G1 phase. β-elemonic acid (1, 3, 10, 20 μM; 24 hours) inhibits phosphorylation of p42/44, MAPK/JNK and p38 in the A549 cells.
-
In Vivo——
-
Synonyms——
-
PathwayWnt/Notch/Hedgehog
-
TargetWnt/beta/catenin
-
RecptorOthers
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number28282-25-9
-
Formula Weight454.69
-
Molecular FormulaC30H46O3
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 25 mg/mL (54.98 mM)
-
SMILESCC(=CCCC(C1CCC2(C1(CCC3=C2CCC4C3(CCC(=O)C4(C)C)C)C)C)C(=O)O)C
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
molnova catalog
related products
-
Nesuparib
Nesuparib (JPI-547/OCN-201) is a potent PARP inhibitor with inhibitory effects on PARP and TNKS1.
-
NRX-252114 B
NRX-252114 (NRX252114) induces degradation of mutant β-catenin NRX-252114 is a potent enhancer of the interaction of β-catenin with the homologous E3 ligase SCFβ-TrCP, and is able to enhance the binding of pSer33/S37A β-catenin to β-TrCP with an EC50 of 6.5 nM and a Kd of 0.4 nM. Kd is 0.4 nM.
-
Roquinimex
Roquinimex (Linomide) is a quinoline derivative immunostimulant which increases NK cell activity and macrophage cytotoxicity; inhibits angiogenesis and reduces the secretion of TNF alpha.
